Basic and Translational Science

Cristancho AG, Tulina N, Anton L, Barila G, Elovitz MA. Intrauterine inflammation leads to some sex and age-specific behavior and molecular differences in mice.  bioRxiv.  BIORXIV/2022/486005.

Gadra EC & Cristancho AG, A simplified mouse model of prenatal hypoxic insult.  Bio-protocol Invited submission (peer-reviewed, under review).

Cristancho AG, Gadra EG, Samba IM, Zhao C, Ouyang M, Magnitsky S, Huang H, Viaene A, Anderson SA, Marsh ED.  Deficits in seizure threshold and other behaviors in adult mice without gross neuroanatomic injury after late gestation transient prenatal hypoxia.  Developmental Neuroscience.  2022; :-. Available from: https://www.karger.com/Article/FullText/524045 DOI: 10.1159/000524045

Joseph DJ, Von Deinmling M, Hasegawa Y, Cristancho AG, Risbud R, McCoy AJ, Marsh ED.  Protocol for isolating adult parvalbumin interneurons from the mouse brain for extraction of high quality RNA.  STAR Protoc. 2021 Aug 4;2(3):100714.  doi: 10.1016/j.xpro.2021.100714. eCollection 2021 Sep 17.

Yardeni T*, Cristancho AG*, McCoy AJ, Schaefer PM, McManus MJ, Marsh ED, Wallace DC.  Endophenotypes in an mtDNA Mutant Mouse Demonstrate That Mitochondrial Deficiency Can Cause Autism.  Proceedings of the National Academy of Sciences.  2021 Feb 9;118(6):e2021429118. doi: 10.1073/pnas.2021429118. *Contributed equally to this work.

Joseph DJ, Von Deinmling M, Hasegawa Y, Cristancho AG, Ahrens-Nicklas RC, Rogers SL, Risbud R, McCoy AJ, Marsh ED.  Postnatal Arx transcriptional activity regulates functional network properties of P.V. interneurons.  iScience.  2020 Dec 28;24(1):101999. doi: 10.1016/j.isci.2020.101999.

Cristancho, AG, Marsh, ED.  Epigenetics Modifiers: Potential Hub for Understanding and Treating Neurodevelopmental Disorders from Hypoxic Injury.  Journal of Neurolodevelopment Disorders.  2020 Dec 16;12(1):37. doi: 10.1186/s11689-020-09344-z.

Tian G*, Cristancho AG*, Dubbs HA, Liu GT, Cowan NJ, Goldberg EM.  A patient with lissencephaly, developmental delay, and infantile spasms, due to de novo heterozygous mutation of KIF2A.  Molecular Genetics and Genomic Medicine.  2016 Nov; 4(6): 599–603. * co-first authors

Clinical Work

Abdelmoumen I, Jimenez S, Valencia I, Melvin J, Legido A, Diaz-Diaz MM, Griffith C, Massingham LJ, Yelton M, Rodriguez J, Schnur RE, Walsh LE, Cristancho AG, Bergqvist CA, McWalter K, Mathieson I, Belbin GM, Kenny EE, Ortiz-Gonzalez XR, Schneider MC.  Boricua founder variant in FRRS1L causes epileptic encephalopathy with hyperkinetic movements.  Journal of Child Neurology.  2020 Sep 15 ;883073820953001.

Mignot C, McMahon AC, Bar C, Campeau PM, … Cristancho AG, … Moller RS, Lesca G, Helbig KL, Nabbout R, Verbeek NE, Depienne C (86 authors). IQSEC2-related encephalopathy in males and females: a comparative study including 37 novel patients.  Genetics in Medicine.  2018 Sep 12.  [Epub]

Gray IN, Cristancho AG, Licht DJ, Liu GT. Ocular Dipping in a Patient With Hemiplegic Migraine.  Journal of Pediatric Ophthalmology and Strabismus.  2018 Jan 31;55:e4-e6.

Early Science Beginnings

Cristancho AG, Lazar MA.  Double SET point: G9a makes its mark in adipogenesis.  EMBO Journal.  2013 Jan 9; 32(1): 4-6. 

Cristancho AG, Lazar MA.  Forming functional fat: a growing understanding of adipocyte differentiation.  Nature Reviews Molecular Cell Biology.  2011 Sep 28;12(11):722-34.

Cristancho AG, Schupp M, Lefterova MI, Cao S, Cohen DM, Chen CS, Steger DJ, Lazar MA. Repressor transcription factor 7-like 1 promotes adipogenic competency in precursor cells.  Proceedings of the National Academy of Sciences.  2011 Sep 27;108(39):16271-6.

Schupp M, Cristancho AG, Lefterova MI, Hanniman EA, Briggs ER, Steger DJ, Qatanani M, Curtin JC, Schug J, Ochsner SA, McKenna NJ, Lazar MA. Re-expression of GATA2 cooperates with peroxisome proliferator-activated receptor-gamma depletion to revert the adipocyte phenotype.  Journal of Biological Chemistry.  2009 Apr 3;284(14):9458-64.

Schupp M, Lefterova M, Janke J, Leitner K, Cristancho AG, Mullican SE, Szwergold N, Steger DJ, Curtin JC, Kim RJ, Suh M, Albert MR, Engeli S, Gudas LJ, and Lazar MA. Retinol Saturase Promotes Adipogenesis and Is Down-Regulated in Obesity.  Proceedings of the National Academy of Sciences.  2009 Jan 27;106(4):1105-10.

Lefterova MI, Zhang Y, Steger DJ, Schupp M, Schug J, Cristancho A, Feng D, Zhuo D, Stoeckert, Jr CJ, Liu XS, and Lazar MA. PPARg and C/EBP Factors Orchestrate Adipocyte Biology Via Adjacent Binding on a Genome-Wide Scale.  Genes and Development.  2008 Nov 1;22(21):2941-52.

Moise AR, Domínguez M, Alvarez S, Alvarez R, Schupp M, Cristancho AG, Kiser PD, de Lera AR, Lazar MA, Palczewski K. Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids.  Journal of the American Chemical Society.  2008 Jan 30;130(4):1154-5.